Archives of Pharmacal Research
- Volume 18 Issue 2
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- Pages.129-132
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- 1995
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
O-Acetyljervine;A New $\beta-adrenoceptor$ agonist from veratrum album
- Anwar-H. Gilani (Department of Pharmacology,The Aga Khan University Medical College) ;
- Khalid-Aftab (HEJ Research Institute of Chemistry, University of Karachi) ;
- S.A. Saeed (Department of Pharmacology,The Aga Khan University Medical College) ;
- Rahat-A. Ali (HEJ Research Institute of Chemistry, University of Karachi) ;
- Rahman, Atta-ur (HEJ Research Institute of Chemistry, University of Karachi)
- Published : 1995.04.01
Abstract
Intravenous administration of O-acetyliervine (an alkaloid from Vertrum album) produced a dose-dependent (10-100 .mu.g/kg) fall in blood pressure and tachycardia in anaesthetized normotensive rats. Pretreatment of animals with propranolol (1mg/kg) abolished these cardiovascular responses of O-acetyljervine similar to that of isoprenaline
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