The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effect of SAENGCHINYANGHYOLTANG on the serum lipid composition in streptozotocin-induced diabetic rats

생진양혈탕(生津養血湯)이 고혈당(高血糖) 쥐의 혈중지질성분(血中脂質成分)에 미치는 영향(影響)

  • Kim, Shin-Seok (College of Oriental Medicine, Tae Jon University,College of Pharmacy, Kyungsung University) ;
  • Choi, Jong-Won (College of Oriental Medicine, Tae Jon University,College of Pharmacy, Kyungsung University) ;
  • Lee, Kyung-Hee (Dept. of Food Science and Nutrition, Dong-A University) ;
  • Lee, Cheol-Whan (Dept. of Food Science and Nutrition, Dong-A University)
  • 김신석 (대전대학교 한의과대학,경성대학교 약학대학) ;
  • 최종원 (대전대학교 한의과대학,경성대학교 약학대학) ;
  • 이경희 (동아대학교 식품영양학과) ;
  • 이철완 (동아대학교 식품영양학과)
  • Published : 1995.10.30
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Abstract

The purpose of this study was to investigate the effect of pretreatment with Saegchinyanghyoltang(SYT) on the serum lipid composition and atherosclerotic index in streptozotocin(STZ)-induced diabetic rats. SYT pretreatment in STZ-induced diabetic rats inhibited the rise of serum glucose concentration. Serum total lipids and triglyceride levels in the STZ -induced diabetic rats were significantly higher than those in the control group. But in the group pretreated with SYT, triglyceride and lipid levels were significantly lower compared with those of STZ -induced diabetic rat group without STZ. However, the serum phospholipid levels were not statistically different among treatment groups. In the STZ-induced diabetic group, the serum total cholesterol, VLDL-, LDL-cholesterol levels and atherosclerotic index Were higher and HDL-cholesterol level was lower compared to the control group. However, these changes were prevented by SYT pretreatment Pretreatment with SYT significantly increased the activities of serum lipase compared to the STZ-treated group.

Keywords

References

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