The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Effect of SAENGCHINYANGHYOLTANG on the hepatic metabolic enzyme system in streptozotocin-induced diabetic rats

고혈당(高血糖) 쥐의 간(肝) 대사효소계(代謝酵素系)에 미치는 생진양혈탕(生津養血湯)의 영향(影響)

  • Published : 1995.10.30
Download PDF
⟨ Previous Next ⟩

Abstract

SANGNYANGHYOLTANG(SYT) is one of the most important prescription that has been used in oriental medicine for diabetes mellitus. The sudy was done in order to elucidate the anti-diabetic effect of SYT. After pretreatment of SYT(1,000mg／kg) for 6 weeks, the effect of of SYT was prevented on serum liver function test and hepatic lipid peroxide content in rats i.v. injected with streptozotocin(STZ, 50mg／kg, tail vein) 5 weeks after pretreatment of SYT. The hepatic microsomal cytochrome P-450 and aniline hydroxylase were significantly decreased, and aminopyrine N-demethylase activity was significantly increased in SYT-STZ group as compared with control group. Changes in aldehyde oxidase, xanthine oxidase, superoxide dismutase, catalase, epoxide hydrolase, UDP-glucuronyltransferase and sulfotransferase activities were not significantly different in any of the group. The cytosolic glutathione S-transferase activity was significantly decreased in SYT-STZ group as compared with control group. The selenium-independent glutathione peroxidase was significantly increased in SYT-STZ group as compared with control group, but there was no significant difference in selenium-dependent glutathione peroxidase in any of the groups. The hepatic glutathione concentration was significantly increased in SYT-STZ group as compared with control group, and ${\gamma}-glutamylcystein$ synthetase and glutathione reductase activities were not significantly different in any of the groups. The hepatic lipid peroxide content, serum aminotransferase and sorbitol dehydrogenase activities were slightly decreased in significantly in SYT-STZ groups.

Keywords

References

  1. 沈氏尊生書 沈金鰲
  2. 古今醫方集成 吳克潛
  3. 東醫寶鑑 許浚
  4. 聖濟總錄 趙佶
  5. 大韓醫學全集 李正來
  6. 簡明方濟辭典 江克潛;包明惠(編箸)
  7. 漢方內科學 李基渟
  8. 中醫內科學 上海中醫學院
  9. 本草學 李尙仁
  10. 本草三家合柱 張隱庵;葉天士;陳修園
  11. 本草綱目 李時珍
  12. 新農本草學 吳普 等(述)
  13. 慶熙大學校 韓醫大 博士論文 消渴에 應用되는 白虎湯이 Alloxan糖尿에 미치는 影響 金完熙
  14. 경희대韓醫大論文集 v.7 加味六味地黃湯이 streptozotocin 白鼠의 血糖量에 미치는 影響 許鐘會
  15. 慶熙大學校 大學院 博士學位 論文 加味地黃湯과 鴨척草가 實驗的 糖尿에 미치는 影響 鄭大奎
  16. 慶熙醫學 v.4 加味地黃湯이 Alloxan 投與 흰쥐의 血糖 및 腎障碍에 미치는 影響 金頸宅
  17. 東西醫學 v.11 no.2 消渴에 應用되는 黃耆湯 加味方이 KK mouse의 代謝 機能에 미치는 影響 李雄禎
  18. 東醫病理學會誌 v.5 玉泉散이 Alloxan 投與 白鼠 血淸의 代謝 機能에 미치는 影響 吳政錫
  19. 大邱韓醫科大學大學院 博士學位論文 加味四物湯이 糖尿에 미치는 影響에 관한 實驗的 硏究 張世煥
  20. 淸心運子散이 Streptozotocin으로 誘發한 白鼠의 高血糖에 미치는 影響 金秀雄
  21. Biochem. J. v.268 Induction of crtorhrome P-450 Ⅲ and P-450 IV family protein in streptozotocin-induced diabetes Barnett, C.R.;Gibson, G.G.;Wolf, C.C.;Flatt, P.R.;Ioannides, C.
  22. Biochem. Pharmacol. v.34 Effect of streptozoiocin on the glutathione S-transferase of liver cytosol Agius, C.;Gidari, A.S.
  23. Biochem. Pharmacol. v.36 Conjugation reactions in hepatocytes isolated from streptozotocin-induced diabetic rats Grant, M.H.;Duthie, S.J.
  24. Toxicol. Appl. Pharmacol. v.93 The effect of long-term streptozotocininduced diabetes in the hepatotoxicity of bromobenzene and carbon tetrachloride and hepatic biotransformation in rats Watkins, J.B.;Sanders, R.A.;Beck, L,V.
  25. Can. J. Physiol. Pharmacol. v.68 Possible role of blood insulin levels on glutathione S-transferase activities from different tissues of male rats Carnovale, C.E.;Monti, J.A.;Catania, V.A.;Carrillo, M.C.
  26. Arch. Biochem. Biophys. v.235 Lipid peroxidation increases the molecular order of microsomal membranes Curtis, M.T.;Gilfor, D.;Farber, J.L.
  27. Arch. Biochem. Biophys. v.236 Lipid photooxidation in erythrocyte ghosts sensitization of membranes toward ascorbate and superoxide-induced peroxidation and lysis Cirotti, A.W.;Thomas, J.P.;Jordan, J.S.
  28. FEBS lett. v.239 Enhancement by streptozotocin of $O^{2}$-radical geneation by the xanthine oxidases system of pancreatic ${\beta}$-cell Nukatsuka, M.;Sakurai, H.;Yoshimura, Y.;Nishida, M.;Kawada, J.
  29. Oxygen free radical scavengers protect rat islet cells from damage by cytokines Diabetologia v.32 Sumoki, W.;barluerizo, H.;Ravinovitch, A.
  30. Diabetes v.38 Oxygen free radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptrzoyocin-induced insulities Mendola, J.;James, R.;Wright, J.R.;Lacy, P.
  31. 大韓韓醫學會誌 v.15 no.2 高血糖쥐의 膵臟酵素 活性에 미치는 生津養血湯의 影響 金信錫;崔鐘元;李哲浣
  32. 大韓韓醫學會誌 生津養血湯이 高血糖 쥐의 血中脂質戊分에 미치는 影響 金信錫;崔鐘元;李慶姬;李哲浣
  33. 方藥合編 黃度淵
  34. Am. J. Clin. Pathol. v.28 A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase Reitman, S.;Frankel, S.
  35. Clinical laboratory methods(9th ed.) Bauer, J.D.
  36. Catalase in Method of enzymatic analysis(H.U. Vergmeyer, ed.) v.2 Aebi, H.
  37. J. Biol. Chem. v.237 Hepatic aldehyde oxidase. In:Purification and properties Rajagopalan, K.V.;Fridovich, I.;Handler, P.
  38. Biochem. Biophys. Res. Common. v.25 Evidence for biochemically different types of vesicles in the hepatic microsomal fraction Imai, I.;Sato, R.
  39. J. Biol. Chem. v.55 The colorimetric estimation of formaldehyde by means of the hentisch reaction Nash, T.
  40. J. Biol. Chem. v.244 The regulation of rat liver xanthine oxidase: Conversion in vitro of the enzyme activity from dehydrogenase(Type D) to oxidase(Type O) Stripe, F.;Delta, C.E.
  41. J. Biol. Chem. v.239 the carbon monooxide binding pigments of liver microsomes, In: Evidence for its hemoprotein nature Omura, T.;Sato, R.
  42. Pharmacol. v.31 Hammock Spectrophotometric assay for mamalian cytosolic epoxide hydrolase using trans-stilbene oxide as the substrate biochem Hasegawa, L.S.;B>D>
  43. J. Biol. Chem. v.250 Regulation of ${\gamma}$-히utamylcystein synthesis by nonallosteric feedback inhibition by glutathione Meister, A.;Ricllman, P.G.
  44. J.Biol. Chem. v.66 the colorimetric determination of phosphorus Fiske, C.H.;Subbarow, Y.
  45. J. Lab. Clin. Med. v.70 Studis on the quantitative and qulitative chara cterization of erythrocytes glutathione peroxidase Pagila, E.D.;Valentine, W.N.
  46. J. Biol. Chem. v.237 Hepatic glutathione reductase. In: Purification and general kinetics properties Mize, C.E.;Langdon, R.G.
  47. J. Biol. Chem. v.249 Glutathione S-transferase:The first step in mercapturic acid formation Habig, W.H.;Pabist, M.J.;Jakoby, W.B.
  48. Biochem. Pharmacol. v.30 Guinea pig intestinal sulfotransferase: An investigation using the cytosol fraction Dawson, J.R.;Bridges, J.W.
  49. Eur. J. Biochem. v.47 Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase Marklund, S.;Marklund, G.
  50. Biochem. Pharmacol. v.35 Diminished rates of glucuronidation and sulfation in perfused rat liver after chronic ethanol administration Reinke, L.A.;Meyer, M.J.;Notley, K.A.
  51. Arch. Biochem. Biophys. v.30 tissue sulfhydryl group, Ellman, G.L.
  52. Assay for lipid peroxide in animal tissues by thi Ohkawa, H.;Ohishi, N.;Yaki, K.
  53. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent Lowry, O.H.;Rosebrough, N.J.;Farrand, A.L.;Rendall, R.J.
  54. New Engl. J. Med. v.303 Normobaric oxygen toxicity of the lung Susan, M.D.;Darry, L.F.
  55. J. Biol. Chem. v.266 Hydrogen peroxide causes the fetal injury to human fibroblasts exposed to oxygen radicals Simonm, R.H.;Scoggin, C.M.;Patterson, D.
  56. Lab. Invest. v.47 Biology of disease Free radicals and tissue injury Freeman, B.A.;Crapo, J.D.
  57. Diabetes v.37 Composition changes in hepatic microsomal cytochrome P-450 dyring onset of streptozotocin-induced diabetes and during insulin treatment Favreau, L.V.;Schenkman, J.B.
  58. Biochem. J. v.264 The effect of streptozotocin-induced diabetes on phenylalanine hydroxylase expression in rat liver Taylor, D.S.;Dahl, H.H.M.;Mercer, J.F.B.;Green, A.K.;Fisher, M.J.
  59. Pharmacol. Toxicoi. v.19 Presysthemic drug elimination, Annu. Res Routledge, P.A.;Shand, D.G.
  60. Mol. Pharmacol. v.3 Spectral studies of drug interaction with hepatic microsomal cytochrome Schenkman, J.B.;Remmer, H.;Estabrook, R.W.
  61. Pharmacol. v.31 Effect of diabetes on rat liver cytachrome p-450 Biochem Murilyn, R.P.;David, C.
  62. Biochem. Biophys. Res. Common. v.142 Decrease in the levels of a constitutive cytochrome P-450 in hepatic microsomes of diabetic rats Leonard, V.;Schenkman, J.B.
  63. Biochem. Pharmacol. v.23 A perspective on the role of chemically reactive metabolite. Ⅱ Alteration in the kinetics of covvalent binding Gilette, J.G.
  64. J. Pharmacol. Exp. Ther. v.236 Depletion of hepatic UDP-glucuronic acid by drugs that areglucuronidated Howell, S.R.;hazelton, G.A.;Klassen, C.D.
  65. Biochem. Pharmacol. v.35 Diminished rates of glucuronidation and sulfation in perfused rat liver after chronic ethanol administration Reike, L.A.;Meyer, M.J.;Notly, K.A.
  66. Biochem. pharmacol. v.33 Inhibition of soluble lutathione S-transferase by diuretic drugs Ahkas, J.T.;Dvies, C.;Ravenscroft, P.J.;Emmerson, B.T.
  67. Biochem. Pharmacol. v.34 Inhibition of purified rat liver glutathione S-transferase isozymes by diuretic drugs Ahokas, J.T.;Nichollas, F.A.;Ravensroft, P.J.;Emmerson, B.T.
  68. 大田大學校 大學院 博士學位論文 生津養血湯이 Streptozotocin糠尿, 酵素活性 및 組織變化에 미치는 影響 金信錫