Journal of Pharmaceutical Investigation
- Volume 25 Issue 4
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- Pages.307-311
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- 1995
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Antihyperlipidemic Activity of Several Traditional Herbal Medicines on Experimental Hyperlipidemia in Rats
고지혈증 랫트를 이용한 수종 전통 한약제의 항고지혈 효과
- Ro, Hwan-Seong (University of Ulsan, College of Medicine) ;
- Ko, Woo-Kyoung (Asan Institute of Life Science) ;
- Kim, Oon-Ja (Asan Institute of Life Science) ;
- Park, Kun-Koo (Asan Institute of Life Science) ;
- Cho, Young-Hwan (Department of Pharmacology, Asan Medical Center) ;
- Park, Hyung-Sup (University of Ulsan, College of Medicine)
- 노환성 (울산대학교 의과대학) ;
- 고우경 (아산생명과학 연구소 민간요법실) ;
- 김운자 (아산생명과학 연구소 민간요법실) ;
- 박건구 (아산생명과학 연구소 민간요법실) ;
- 조영환 (아산재단 서울중앙병원 약제부) ;
- 박형섭 (울산대학교 약학대학)
- Published : 1995.12.20
Abstract
Three herbal medicine recipes were tried on the animal model of diet induced hypercholesterolemia to screen for the lipid-lowering effect. The recipes adopted were based on the prescription for atherosclerosis-related symptoms by folk-medicine practioners. Hyperlipidemia was induced in rats by giving the high lipid/cholesterol diet for 7 days. Then, the recipes started with the normal diet. Blood was sampled at 1,2,3 and 5 week-points of the treatment, and levels of total cholesterol, triglyceride, high density lipoprotein and lower density lipoprotein were measured. Dae-shiho-tang decreased total cholesterol level significantly. Hwangryun-haedok-tang and Samhwang-sasim-tang slightly decreased total cholesterol level, although it was not statistically significant.
Keywords
- Herbal medicine recipes;
- Hypercholebterolemia;
- Lipid-lowering effect;
- Total cholesterol;
- Dae-shiho-tang