Journal of Pharmaceutical Investigation
- 제25권3호
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- Pages.249-264
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- 1995
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
5-Fluorouracil과 그 유도체를 봉입한 Multilamellar Vesicle(MLV)과 Microemulsified Liposome(MEL)의 특성 및 약물방출 거동
Characteristics and Drug Release Profiles of Multilamellar Vesicle(MLV) and Microemulsified Liposome(MEL) Entrapped 5-Fluorouracil and Its derivatives
- Jee, Ung-Kil (College of Pharmacology, Chungnam National University) ;
- Park, Mok-Soon (College of Pharmacology, Chungnam National University) ;
- Lee, Gye-Won (College of Pharmacology, Chungnam National University) ;
- Lyu, Yeon-Geun (College of Pharmacology, Chungnam National University)
- 발행 : 1995.09.20
초록
Although liposome has many advantages as a pharmaceutical dosage form, its application in the industrial field has been limited because of some problems such as preparation method, reproducibility, scale-up, stability and sterilization etc. Liposomes prepared by microemulsification method had defined size, narrow size distribution, reproducibility and high entrapment efficiency. For enhancing the stability, the dry form of liposome was recommended. These types of liposome are proliposome and freeze-dried liposome. The liposome must have some properties for preparing of freeze-dried liposome; small size
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