Journal of Pharmaceutical Investigation
- 제25권3호
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- Pages.239-247
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- 1995
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
완충 수용액중 pH, 온도, 이온강도 및 금속이온이 Aucubin의 분해에 미치는 영향
Influence of pH, Temperature, Ionic Strength and Metal Ions on the Degradation of an Iridoid Glucoside, Aucubin, in Buffered Aqueous Solutions
- Chun, In-Koo (College of Pharmacy, Dongduck Women's University) ;
- Cho, Young-Mee (College of Pharmacy, Dongduck Women's University)
- 발행 : 1995.09.20
초록
The physico-chemical stability of aucubin, a hepatoprotective iridoid glucoside, in buffered aqueous solutions was studied using a stability-indicating reversed-phase high performance liquid chromatography. The degradation of aucubin followed the pseudo-first-order kinetics. In strong acidic regions, aucubin was rapidly degraded by the specific acid catalysis, forming dark brown precipitates. From the rate-pH profiles, it was found that aucubin was most stable at the pH of about 10. From the temperature dependence of degradation, activation energies for aucubin at pH 2.1 and 4.9 were calculated to be 22.0 and 24.3 kcal/mole, respectively. The shelf-life