Journal of Pharmaceutical Investigation
- 제25권3호
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- Pages.177-184
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- 1995
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
상피세포성장인자의 수용성 외용제제화
Formulation of Water-soluble Topical Preparations of Epidermal Growth Factor
- Lee, Yoo-Cheol (College of Pharmacy, Sung Kyun Kwan University) ;
- Park, Eun-Seok (College of Pharmacy, Sung Kyun Kwan University) ;
- Chi, Sang-Cheol (College of Pharmacy, Sung Kyun Kwan University)
- 발행 : 1995.09.20
초록
In order to formulate an aqueous topical preparation of epidermal growth factor(EGF) for the treatment of open wound and bum, the stability of EGF in aqueous vehicles containing various stabilizers was evaluated and the pharmacological activity of gel preparations formulated with poloxamer 407 was determined with wound model. Various additives, which are known as potent stabilizers for proteins and polypeptides so far, were used to increase the stability of EGF in aqueous vehicles. The contents of EGF in the vehicles containing stabilizers were determined with an HPLC method after the storage at