생약학회지 (Korean Journal of Pharmacognosy)
- 제26권1호
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- Pages.47-50
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- 1995
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
지모(知母)의 항암활성성분에 관한 연구
Antitumor Agent from the Rhizome of Anemarrhena asphodeloides
- 이승호 (영남대학교 약학대학) ;
- 유시용 (한국화학연구소) ;
- 최상운 (한국화학연구소) ;
- 노재성 (한국화학연구소) ;
- 김성기 (한국화학연구소) ;
- 이정옥 (한국화학연구소) ;
- 안종웅 (한국화학연구소)
- Lee, Seung-Ho (College of Pharmacy Yeung Nam Univ.) ;
- Ryu, Shi-Yong (Korea Research Institute of Chemical Technology (KRICT)) ;
- Choi, Sang-Un (Korea Research Institute of Chemical Technology (KRICT)) ;
- No, Zae-Sung (Korea Research Institute of Chemical Technology (KRICT)) ;
- Kim, Sung-Ki (Korea Research Institute of Chemical Technology (KRICT)) ;
- Lee, Chong-Ock (Korea Research Institute of Chemical Technology (KRICT)) ;
- Ahn, Jong-Woong (Korea Research Institute of Chemical Technology (KRICT))
- 발행 : 1995.03.30
초록
EtOAc soluble part of MeOH extract of Anemarrhena asphodeloides rhizome was evaluated for the cytotoxicity against the five kinds of human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15) in vitro. Bioassay-guided fractionation of EtOAc soluble part led to the isolation of active compound which was identified as timosaponin A-III showed potent cytotoxic activity, but its genin, sarsasapogenin, did not show cell growth inhibition.
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