'The effects of Chungsimgangwhawhan (淸心降火丸) on blood pressure and hyperlipidemia'

청심강화환(淸心降火丸)이 고혈압(高血壓) 및 고지혈증(高脂血症)에 미치는 영향(影響)

In order to study the effects of Chungsimgangwhawhan on blood pressure in normal rats and rabbits, and hyperlipidemia induced by 1% cholesterol diet, triton WR-1339, and 75% fructose in mice and rats, the amount of total cholesterol, triglyceride, phospholipid and blood pressure were measured. The results were as follows : 1. After per os medication of Chungsimgangwhawhan, blood pressure in rats were increased but were not significant. 2. Chungsimgangwha-Whan showed strong effects on decreasing blood pressure, depending on the concentration in blood vessels of rabbits. 3. In the model of hyperlipidemia induced by 1% cholesterol diet in mice, Chungsimgangwhawhan showed decreasing effects on total cholesterol level in serum significantly (p<0.05) depending on the concentration, and on triglyceride (p<0.01) and phospholipid level (p<0.001) in serum. 4. In the model of hyperlipidemia induced by triton WR-1339 in rats, Chungsimgangwhawhan showed mild decreasing effects on total cholesterol level in serum, but was not significant. 5. In the model of hyperlipidemia induced by 75% fructose in rats, Chungsimgangwhawhan showed decreasing effects on total cholesterol and triglyceride level in serum significantly(p<0.01) depending on the concentration. According to the above results, Chungsimgangwhawhan showed significant decreasing effects on blood pressure and hyperlipidemia, and it is considered that it is appropriate to apply for hypertension and hyperlipidemia.