The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Two Cases Report of Epidural Clonidine Analgesia in Cancer Patient and in Patient Tolerant to Opioids

Epidural Clonidine의 제통효과에 관한 증례 2례 보고

  • Kim, Byung-Jung (Department of Anesthesiology, College of Medicine, Hallym University) ;
  • Kim, Young-Mi (Department of Anesthesiology, College of Medicine, Hallym University) ;
  • Kwon, Kwang-Jun (Department of Anesthesiology, College of Medicine, Hallym University) ;
  • Yoon, Young-Joon (Department of Anesthesiology, College of Medicine, Hallym University) ;
  • Jin, Sang-Ho (Department of Anesthesiology, College of Medicine, Hallym University)
  • 김병중 (한림대학교 의과대학 마취과학교실) ;
  • 김영미 (한림대학교 의과대학 마취과학교실) ;
  • 권광준 (한림대학교 의과대학 마취과학교실) ;
  • 윤영준 (한림대학교 의과대학 마취과학교실) ;
  • 진상호 (한림대학교 의과대학 마취과학교실)
  • Published : 1994.11.26
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Abstract

The central antihypertensive agent clonidine is an ${\alpha}_2$-adrenergic agonist that possesses pain-relieving properties. It has been administered epidurally in the treatment of cancer pain and for postoperative analgesia. 1) Case 1, 62-year-old woman who suffered from neurogenic pain syndrome due to metastatic squamous cell carcinoma of spinal canal was treated. 2) Case 2, 51-year-old woman undergoing lower abdominal surgery, epidurally administered morphine did not produced postoperative analgesia. In these cases, continuous epidural administeration of clonidine (200ug/day) and 0.3% bupivacaine(12 ml/day) produce high quality pain relief. These results suggest that antinociceptive effect of epidural clonidine is assumed to result from activation of ${\alpha}_2$-adrenergic receptors in the dorsal horn of the spinal cord.

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