Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Effects of Flavonoids and a-Tocopherol on the Oxidation of n-3 Polyunsaturated Fatty Acids -2. Antioxdizing Effect of Catechin and a-Tocopherol in Rats with Chemically Induced Lipid Peroxidation-

n-3 고도 불포화 지방산의 산화억제에 미치는 플라보노이드와 a-토코페롤의 효과 -2. 지질과산화를 촉진시킨 흰 쥐의 체내지질의 산화 억제 효과-

  • BYUN Dae-Seok (Department of Nutrition and Food Science, National Fisheries University of Pusan) ;
  • KWON Mi-Na (Department of Nutrition and Food Science, Inje University) ;
  • HONG Jeong-Hwa (Department of Nutrition and Food Science, Inje University) ;
  • JEONG Dong-Yoon (Department of Nutrition and Food Science, National Fisheries University of Pusan)
  • 변대석 (부산수산대학교 식품영양학과) ;
  • 권미나 (인제대학교 식품영양학과) ;
  • 홍정화 (인제대학교 식품영양학과) ;
  • 정동윤 (부산수산대학교 식품영양학과)
  • Published : 1994.03.01
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Abstract

To evalulate the antioxidant effect of flavonoid(+)-catechin on n-3 polyunsaturated fatty acids in vivo, rats were fed with diets containing $5\%$ corn oil(CO), $5\%$ corn oil and $15\%$ purified fresh fish oil(FO) or peroxidized fish oil(PFO) for 10 days. To accerelate lipid peroxidation, all of them were injected with 60mg phenobarbital(a day per kg body weight), and treated with phorone(diisopropylidene acetone) before the rats were killed. Contents of triglyceride, phospholipid, cholesterol and lipid peroxide and the activities of GOT, GPT in serum and total lipid and cholesterol content in liver of PFO group rats were significantly higher than those of the FO one. Contrary to our expectations, the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase(GSH-Px) in liver of the FO group were ]ewer than those of the PFO group. These results might be explained as the results of homeostasis. Even though the hepatic glutathione were depleted, catechin and a-tocopherol inhibited production of lipid peroxide effectively. These results suggested that catechin be considered an antioxidative and hepatoprotective agent.

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