Journal of Food Hygiene and Safety (한국식품위생안전성학회지)
- Volume 9 Issue 2
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- Pages.75-80
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- 1994
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- 1229-1153(pISSN)
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- 2465-9223(eISSN)
Effects of Ursodeoxycholic Acid on Acute Hepatic Lesion
Ursodeoxycholic acid가 급성 간손상에 미치는 영향
Abstract
The effects of ursodeoxycholic acid (UDCA) were studied on the hepatotoxicity induced by several hepatotoxicants such as carbonte trachloride, thioacetamide and 1-naphthylisothiocyanate in ICR male mice. UDCA (50 mg/kg, 100 mg/kg) decreased the elevated serum bilirubin in carbon tetrachloride intoxicated mice, the elevated serum AST, alkaline phosphatase in thioacetamide intoxicated mice, the elevated serum AST and bilirubin in 1-naphthylisothiocyanate intoxicated mice.
Keywords
- Ursodeoxycholic acid;
- Carbon tetrachloride;
- Thioacetamide;
- 1-naphthylisothiocyanate;
- s-AST;
- s-ALT;
- Alkaline phosphatase;
- Bilirubin