Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
권호 표지

Studies on the Genotoxicity of the Gamma-irradiated Panax Ginseng Radix In Vitro and In Vivo

방사선조사 인삼의 유전독성에 관한 연구

  • 하광원 (국립보건안전연구원 독성부) ;
  • 정해관 (국립보건안전연구원 독성부) ;
  • 오혜영 (국립보건안전연구원 독성부) ;
  • 허옥순 (국립보건안전연구원 독성부) ;
  • 손수정 (국립보건안전연구원 독성부) ;
  • 한의식 (국립보건안전연구원 독성부) ;
  • 정성철 (국립보건안전연구원 독성부) ;
  • 최부영 (국립보건안전연구원 독성) ;
  • 김영미 (국립보건안전연구원 독성부)
  • Published : 1994.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was aimed to find out the comparative effects between non-irradiated, and 5kGy-10kGy of gamma-irradiated Panax Ginseng Radix powder on the genotoxicity for identification of possibility of DNA damage causing cancer. Four different short-term mutagenicity tests were used: (1) Salmonella typhimurium reversion assay (Ames test) (2) Chromosome aberration test in cultured Chinese hamster lung (CHL) fibroblast cells. (3) Micronucleus test in ddY mouse (4) Somatic mutation and recombination test in the wing cells of Drosophila melanogaster.Gamma-irradiated Panax Ginseng Radix powder revealed negative results in these four mutagenicity tests. This means gamma-irradiated ginseng could be safe on the genotoxic point of view.

Keywords