대한약리학회지 (The Korean Journal of Pharmacology)
- 제30권3호
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- Pages.331-336
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- 1994
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- 0377-9459(pISSN)
동맥경화 예방과 치료를 위한 연구시도: Nitric Oxide의 역활 -광 유도 nitric oxide(PIANO)의 혈관이완에 따른 cyclic GMP의 증가
Possible Role of Nitric Oxide in Prevention of Atherosclerosis: Photo-induced adequate nitric oxide (PIANO)-mediated relaxation involves cyclic GMP increment
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장기철
(경상대학교 의과대학 약리학교실) ;
- 정원석 (경상대학교 의과대학 약리학교실) ;
- 박병욱 (경상대학교 의과대학 약리학교실) ;
- 이승엽 (경상대학교 의과대학 약리학교실) ;
- 고학준 (경상대학교 의과대학 약리학교실)
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Chang, Ki-Churl
(Departments of Pharmacology and Cardiovasular Research Institute, College of Medicine, Gyeongsang National University) ;
- Chong, Won-Seog (Departments of Pharmacology and Cardiovasular Research Institute, College of Medicine, Gyeongsang National University) ;
- Park, Byung-Wook (Departments of Pharmacology and Cardiovasular Research Institute, College of Medicine, Gyeongsang National University) ;
- Lee, Seung-Youb (Departments of Pharmacology and Cardiovasular Research Institute, College of Medicine, Gyeongsang National University) ;
- Ko, Hak-Joon (Departments of Pharmacology and Cardiovasular Research Institute, College of Medicine, Gyeongsang National University)
- 발행 : 1994.12.30
초록
본 연구의 목적은 광 유도에 의한 nitric oxide (PIANO)유리가 혈관이완에 대해 cyclic GMP (cGMP)가 관여하는 지의 여부와 아울러
Our purpose was to know whether photo-induced adequate nitric oxide (PIANO)-mediated relaxation of rat aorta is involved in cyclic GMP increment as well as inhibition of phosphatidylinositide hydrolysis due to phenylephrine (PE). Isometric tension was measured in vitro in response to either agents that modulate NO production or release NO by photolysis of photosensitizing agents in rat aorta that had been contracted with PE submaximally. PIANO-mediated relaxation was accompanied by increment of cyclic GMP, which was dependent on the intensity and duration of light exposure and concentration of photosensitizers. Phosphatidylinositide (PI) turnover augmented by PE was significantly inhibited by PIANO. These findings indiate that cGMP increment is responsible for PIANO-mediated relaxation and which may account for the inhibition of PI turnover due to