YAKHAK HOEJI (약학회지)
- Volume 38 Issue 5
- /
- Pages.520-524
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- 1994
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- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Synthesis and Antimicrobial Activity of 7-[(3-Methylthio or 3-Methylthiomethyl) -3-pyrrolinyl]quinolone-3-carboxylic Acids
7-[(3-메틸티오 또는 3-메틸티오메틸)-3-피롤리닐]퀴놀론-3-카르복실산의 합성과 항균작용
- Lee, Jae-Wook (R&D Center, Dae Woong Pharmaceutical Co. Ltd.) ;
- Son, Ho-Jung (R&D Center, Dae Woong Pharmaceutical Co. Ltd.) ;
- Lee, Kyu-Sam (R&D Center, Dae Woong Pharmaceutical Co. Ltd.) ;
-
Yu, Young-Hyo
(R&D Center, Dae Woong Pharmaceutical Co. Ltd.)
;
- Kim, Dae-Young (Department of Chemistry, Soonchunhyang University)
- 이재욱 ((주)대웅제약 중앙연구소) ;
- 손호정 ((주)대웅제약 중앙연구소) ;
- 이규삼 ((주)대웅제약 중앙연구소) ;
-
유영효
((주)대웅제약 중앙연구소)
;
- 김대영 (순천향대학교 화학과)
- Published : 1994.10.30
Abstract
A number of 7-[(3-methylthio or methylthiomethyl)-3-pyrrolinyl] quinolone-3-carboxylic acids were synthesised by condensation of 7-fluoro substituted quinolone-3-carboxylic acid with 3-methylthio-3-pyrroline or 3-methylthiomethyl-3-pyrroline. The in vitro antimicrobial activity of them were tested against twenty species of Gram-positive or Gram-negative microorganisms. It showed remarkable antibacterial activity, particularly against Gram-positive microoganisms. Among those 1-cyclopropyl-6,8-difluoro-7-[(3-methylthiomethyl) -3-pyrrolinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid(12a) and 1-cycl opropyl-6-fluoro-8-chlore-7-[(3-methylthiomethyl)-3-pyrrolinly]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid(12b) showed the most potent in vitro antibacterial activity.
Keywords
- 3-methylthiomethyl-3-pyrroline;
- 3-methylthio-3-pyrroline;
- quinolone antibacterial;
- antibacterial activity