YAKHAK HOEJI (약학회지)
- Volume 38 Issue 5
- /
- Pages.496-503
- /
- 1994
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Effect of Antacids, Aceglutamide Aluminium or Their Combination on Acute and Chronic Ulcer Models in Rats
흰쥐의 급만성궤양모델에서 제산제와 Aceglutamide aluminium의 병용효과
- Jang, Byeong-Su (R/D Center, Daewoong Pharm, Co. Ltd.) ;
- Yeom, Je-Ho (R/D Center, Daewoong Pharm, Co. Ltd.) ;
- Kang, Jin-Suk (R/D Center, Daewoong Pharm, Co. Ltd.) ;
-
Yu, Young-Hyo
(R/D Center, Daewoong Pharm, Co. Ltd.)
;
- Park, Myung-Hwan (R/D Center, Daewoong Pharm, Co. Ltd.) ;
- Kim, Woon-Ja (Natural Product Research Institute, Seoul National University) ;
- Chun, Sun-A (Natural Product Research Institute, Seoul National University) ;
- Kim, Sang-Mee (Natural Product Research Institute, Seoul National University) ;
-
Lee, Eun-Bang
(Natural Product Research Institute, Seoul National University)
- 장병수 ((주) 대웅제약 중앙연구소) ;
- 염제호 ((주) 대웅제약 중앙연구소) ;
- 강진석 ((주) 대웅제약 중앙연구소) ;
-
유영효
((주) 대웅제약 중앙연구소)
;
- 박명환 ((주) 대웅제약 중앙연구소) ;
- 김운자 (서울대학교 천연물과학연구소) ;
- 천선아 (서울대학교 천연물과학연구소) ;
- 김상미 (서울대학교 천연물과학연구소) ;
-
이은방
(서울대학교 천연물과학연구소)
- Published : 1994.10.30
Abstract
The combined products of antacids(AM) composed of aluminium hydroxide, magnesium hydroxide, and simethicone with a ratio of 1 : 1 : 0.1 and aceglutamide aluminium(AGA) were assayed for the antiulcer activity. The effect of the antacids(AM) in concurrent treatment with AGA was studied in acute gastric lesion induced by Shay's method, stress, ethanol, and indomethacin, in chronic gastric ulcers induced by acetic acid, and in duodenal ulcer induced by mepirizole. In all experimental models, the combined treatment of AM and AGA in the ratio of 2.3:1 showed significant potentiation in inhibition against acute gastric and duodenal ulcer and revealed a significant potentiation of the healing of chronic gastric ulcer.
Keywords
- Antacids[$Al(OH)_3$, $Mg(OH)_2$, simethicone];
- Aceglutamide aluminium;
- Gastric ulcer;
- Duodenal ulcer