Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Facile Syntheses and Multi-orthofunctionalizations of Tertiary Benzamides

  • Paek, Kyung-Soo (Department of Chemistry, Soongsil University) ;
  • Kim, Kyung-Mo (Department of Chemistry, Soongsil University) ;
  • Kim, You-Seung (Division of Applied Science, Korea Institute of Science and Technology)
  • Published : 1993.12.20
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Abstract

Good yields were usually obtained in Pd(O)-catalyzed Suzuki aryl-aryl coupling reaction, even when both coupling partners had an ortho tertiary benzamide functional group. The direct ortho functionalization of oligomeric tertiary benzamides at Snieckus condition is dependent on the chain length. Tertiary benzamide 1 can be o,o-dilithiated only by metal-halogen exchange of the 2,6-dihalo-compound. Bis-tertiary benzamide 9 can be o,o'-dilithiated with excess(4.1 equivalents) s-butyllithium/TMEDA as the lithiating agent. Tris-tertiary benzamide 21 is hard to o,o"-difunctionalize due to steric interactions among the tertiary benzamide functional groups, and due to steric interactions between these functional groups and others (if present) on the termini of the terphenyl unit.

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  1. ChemInform Abstract: Facile Syntheses and Multi-Orthofunctionalizations of Tertiary Benzamides. vol.25, pp.21, 1994, https://doi.org/10.1002/chin.199421115