Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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METABOLISM AND DISPOSITION OF CHLORZOXAZONE IN RATS: EFFECTS OF ETHANOL AND DISULFIRAM

  • Kim, Dong-Hyun (Dopin Control Center, Korean Advanced Institute of Science and Technology) ;
  • Park, Misuk (Dopin Control Center, Korean Advanced Institute of Science and Technology) ;
  • Park, Jongsei (Dopin Control Center, Korean Advanced Institute of Science and Technology)
  • Published : 1993.06.01
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Abstract

Role of rat cytochrome P-450 2E1(P-450 2E 1) in the metabolism of chlorzoxazone was examined by using several approaches' (1) selective inhibiton of catalytic activity in rat liver microsomes by diethyldithiocarbamate, (2) correlation of dimethylnitrosomine N-demethylation with chlorzoxazone 6-hydroxylation, and (3) immunoinhibition of catalytic activity with rabbit anti-rat P-450. The results indicated that P-450 2E1 is responsible for the metabolism of chlorzoxazone.

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References

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