Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
권호 표지

Induction Chemotherapy Plus Radiation Compared with Surgery Plus Radiation in Patients with Advanced Laryngeal and Hypopharyngeal Cancer

진행된 후두암과 하인두암의 환자에서 유도화학 요법 후 방사선 치료와 수술 후 방사선 치료의 성적 비교 및 고찰

  • Keum Ki Chang (Department of Radiation Oncology, Yonsei University College of Medicine) ;
  • Lee Chang Geol (Department of Radiation Oncology, Yonsei University College of Medicine) ;
  • Kim Gwi Eon (Department of Radiation Oncology, Yonsei University College of Medicine) ;
  • Lee Kyung Hee (Yonsei University College of Medicine, Yonsei Cancer Center)
  • 금기창 (연세대학교 의과대학 치료방사선과) ;
  • 이창걸 (연세대학교 의과대학 치료방사선과) ;
  • 김귀언 (연세대학교 의과대학 치료방사선과) ;
  • 이경희 (연세대학교 의과대학 연세암센터)
  • Published : 1993.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Background: We peformed a retroslective study in patients with previously untreated advanced (Stage III or IV) laryngeal and hypopharyngeal cancer to compare the results of induction chemotherapy followed by definitive radiation therapy (CT+ RT) with those of conventional laryngectomy and postoperative radiation therapy (OP + RT). Method: Between 1985 and 1990, twenty-four patients were treated with two or three courses of chemotherapy and radiation therapy (66-75 Gy). Twenty-five patients were received laryngectomy and radical neck dissection (except 3 patients) and postoperative radiation therapy (55~64 Gy). Result: After a median fellow-up of 20 months, the actusrial 5-year overall survival rate was $24\%$ (chemotherapy group) and $36\%,$ (op group). (P>0.1). The local control rate was the $65\%,$ (13/20) and $68.2\%,$ (15/22). (p>0.1). The rate of laryngeal preservation was $65\%$ (13/20) in chemotherapy group. Conclusion: Induction chemotherapy and definitive radiation therapy can be effective in preserving the larynx in a high percentage of patients with advanced laryngeal and hypopharyngeal cancer.

Keywords