The Korean Journal of Pharmacology (대한약리학회지)
- Volume 29 Issue 1
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- Pages.23-32
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- 1993
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- 0377-9459(pISSN)
Studies on Involvement of Central GABAergic Mechanism and Central ${\alpha}_{2}-Adrenoceptors$ in Pressor Responses to Raised Intracranial Pressure
두개내압상승에 의한 혈압상승작용과 중추 GABA계 및 중추 ${\alpha}_{2}$ -아드레날린 수용체와의 관계
- Kim, Yung-Sik (Department of Pharmacology, Chonnam University Medical School)
- 김영식 (전남대학교 의과대학 약리학교실)
- Published : 1993.06.30
Abstract
Recent studies have shown that a GABAergic mechanism in the brain modulates arterial blood pressure (BP) through alterations of sympathetic activity in the brain. The purpose of the present study was to determine if this modulation is involved in the pressor response to raised intracranial pressure (ICP). The pressor response to raised ICP was abolished by pretreatment of anesthetized rabbits with intracerebroventricular (icv) muscimol (a GABA agonist) as well as with icv clonidine
GABA계가 뇌내의 교감신경계기능에 영향을 주어서 혈압조절에 관여함이 알려져 있다. 본 연구에서는 마취가토에서 GABA계가 두개내압증가에 의한 혈압상승에 관여하는가를 조사하였다. 두개내압증가에 의한 승압은 측뇌실내 muscimol (GABA 작용약)이나 clonidine
Keywords
- Rabbit blood pressure;
- Intracranial pressure;
- Muscimol;
- Clonidine;
- Yohimbine;
- Bicuculline;
- Intracerebroventricular injection;
- GABAergic sites;
- ${\alpha}_{2}-adrenoceptors$