Toxicological Research
- 제8권2호
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- Pages.317-329
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- 1992
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
화학 발암물질에 대한 인체 암 위해성 평가
Methodology of Human Cancer Risk Assessment for Chemical Carcinogens
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이병무
(성균관 대학교 약학대학)
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Lee, Byung-Mu
(Division of Toxicology, College of Pharmacy, Sung Kyun Kwan University)
- 발행 : 1992.12.01
초록
Fifty chemicals are currently classified as human carcinogens based on epidemiologic and animal data. Humans are daily exposed to them from various sources of exposure via inhalation, dermal contact and oral ingestion. To reduce cancer risk to man, these human carcinogens should be appropriately regulated and monitored environmentally or biologically for routine human cancer risk assessment. A number of mathematical risk assessment models have been introduced, but any realistic and relevant model system is not available for humans. A mechanistic process for human cancer risk assessment was comprehensively reviewed and problems were also discussed. Here, a new conceptual approach using epidemiology and biological human monitoring was suggested for the most relevant method to study human cancer risk assessment.