Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

THE STUDY ON CARCINOGENICITY OF COPTIS RHIZOME AND CROTON TIGLIUM L.

  • Kang, Kyung-Sun (College of Veterinary Medicine, Seoul National University) ;
  • Cho, Jae-Jin (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Bae-Hwan (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Hyung-Ook (College of Veterinary Medicine, Seoul National University) ;
  • Shin, Dong-Jin (College of Veterinary Medicine, Seoul National University) ;
  • Lee, Yong-Soon (College of Veterinary Medicine, Seoul National University) ;
  • Lim, Yoon-Kyu (College of Agriculture, Cheju National University)
  • Published : 1992.06.01
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Abstract

Sprague-Dawley rats aged six weeks divided into four groups and group 1, 2, 3 and 4 of rats were given an intrapertioneal injection of diethylnitrosamine at 200 mg/kg body weight. Group 4 was Control. Two weeks after beginning of the experiment, group 1 of rats were begun to feed on water containing 0.05% phenobarbital sodium as a promoter for six weeks, and CP-2 were intrapertioneally given to rats of group 2(20mg/kg) and group 3(1mg/kg). Three weeks after beginning of the experiment, partial hepatectomy was performed in all rats. Preneoplastic foci were identified histopathologically by glutathione S-transferase placental form (GST-P) activity. In the Immunohistochemical quantitative analysis of carcinogen-induced foci, it was concluded that CP-2 was not carcinogen.

Keywords

References

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