초록
This study was carried out to investigate the effect of samyootang and shinchulsan extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate it's mechanism The isolated were obtained as follows ; 1. The isolated trachea smooth muscle was suspended in the organ bath with oxygenated kreb's Henseleit bicarbonate buffer solution at $37^{\circ}C$, and the developed tension by the drug was recored with Isometric transducer (nacro F-60) The resting tension was approximately 0.5g 2. The contractile response of the trachea smooth muscle of the isolated guinea pig to histamine $10^{-4}M$ was significantly inhibited by samyootang and shinchulsan extract. 3. The contractile response of the trachea smooth muscle of the isolated guinea pig to acetylcholine $10^{-4}M$ was considerably inhibited by samyootang and shinchulsan extract. 4. The contractile response of the trachea smooth muscle of the isolated guinea pig to histamine $10^{-4}M$ was significantly inhibited by samyootang and shinchulsan extract. 5. The contractile response of the trachea smooth muscle of the isolated guinea pig to acetylcholine $10^{-4}M$ was significantly inhibited by samyootang and shinchulsan extract.