YAKHAK HOEJI (약학회지)
- Volume 36 Issue 1
- /
- Pages.17-25
- /
- 1992
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
General Pharmacology of Recombinant Human Growth Hormone without N-Terminal Methionine Expressed in Saccharomyces cerevisiae
효모에서 발현된 유전자 재조합 탈메치오닌 인간 성장호르몬의 일반 약리작용
- Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
- Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
- Kim, Oon-Ja (Natural Products Research Institute, Seoul National University) ;
- Yoon, Ki-Young (Natural Products Research Institute, Seoul National University) ;
- Cheon, Seon-Ah (Natural Products Research Institute, Seoul National University) ;
- Chae, Yun-Jung (Natural Products Research Institute, Seoul National University)
- 이은방 (서울대학교 생약연구소) ;
- 신국현 (서울대학교 생약연구소) ;
- 김운자 (서울대학교 생약연구소) ;
- 윤기영 (서울대학교 생약연구소) ;
- 천선아 (서울대학교 생약연구소) ;
- 채윤정 (서울대학교 생약연구소)
- Published : 1992.02.29
Abstract
The general and some other pharmacological actions of growth hormone without N-terminal methionine(rhGH) were investigated in animals. The hormone had no influences on the central nervous system and on body temperature at a high oral dose of 40 IU/kg in animals. It had neither analgesic nor antiepileptic actions at the high doses. In the isolated ileum and trachea of guinea-pig and isolated stomach fundus and uterus of rat, it showed neither contractive nor relaxing effects at a concentration of