Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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MOLECULAR CONTROLS OF EPIDERMAL GROWTH AND DIFFERENTIATION: TRANSFORMING GROWTH FACTORE

  • Son, Youngsook (Howard huges Medical Institute) ;
  • Fuchs, Elaine (Department of Molecular Genetics and Cell Biology The University of Chicago)
  • Published : 1991.12.01
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Abstract

In the epidermis of skin, a fine balance exists between proliferating progenitor cells and terminally differentiating cells. We examined the effects of TGF-betas and retinoic acid (RA) on controlling this balance in normal human epidermal keratinocytes cultured under conditions where most morphological and biochemical features of epidermis in vivo are retained. Our results revealed marked and pleiotropic effects of both TGF-beta and RA on kerationcytes. In contrast to retinoids, TGF-betas acted on mitotically active basal cells to retard cell proliferation.

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References

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