Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

STUDIES OF VARIOUS FACTORS ON INDUCTION OF EXPERMIMENTAL HEPATOCARCINOGENESIS IN SPRAUGE-DAWLEY RATS

  • Jeong, Ja-Young (College of Veterinary Medicine Seoul National University) ;
  • Kim, Hyoung-Chin (College of Veterinary Medicine Seoul National University) ;
  • Lee, Yong-Soon (College of Veterinary Medicine Seoul National University)
  • Published : 1991.06.01
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Abstract

This study was carried out to investigate the various factors on induction of experimental hepatocarcinogenesis in Sprauge-Dawley rats. The experimental animals were divided into three Experiment. Experiment I, II and III were began rats with initial age of 6, 16 and 55 weeks, respectively. All Experiment were injected intrapertioneal with diethylnitrosamine (DENA` 200 mg/kg) as an intiator and group 3, 4 of Experiment I, II and III were fed on diet containing 0.02% 2-acetylaminofluorene (2-AFF) as a promoter for 6 weeks. Three weeks after two-thirds partial hepatectomy was performed in group 2, 4 of Experiment I & II and group 3 of Experiment III.

Keywords

References

  1. Exp. Pathol. v.19 Carcinogenesis and aging. I. Modifying effects of aging on N-methyl-n-nitrosouria-induced carcinogenesis in female rats Anisimov,V.N.
  2. Carcinogens: Identification and mechanisms of action Theoretical and practical aspects of the two-stage mechanism of carcinogenesis Berenblum,I.;Giriffin,A.C.(ed.);Shaw,C.R.(ed.)
  3. J. Natl. Cancer Res. v.34 Some biological aspects of skin carcinogenesis Boutwell,R.K.
  4. Nature v.289 The origin of human cancers Cairns,J.
  5. Cancer Res v.41 Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures Columbano,A.;Rajalakshmi,S.;Sarma,D.S.R.
  6. Toxicol. Appl. Pharmacol. v.68 The effects of age and expoure duration on cancer induction by a known carcinogen in rats, mice, and hamsters Drew,R.t.;Boorman,G.A.;Haseman,J.K.;McConnell,E.E.;Busey,W.M.;Moore,J.A.
  7. Cancer Res. v.29 The prodduction of hemangioendotheliosarcoma in rats by feeding 5-acetamido-3-(5-nitro-2-furyl)-6H-1,2,4-oxaldiazine Erturk,E.;Cohen,S.M.;Price,J.M.;von Esch,A.J.;Crevetti,A.J.;Bryon,G.T.
  8. Cancer Res. v.44 The multistep nature of cancer development Farber,E.
  9. J. Natl. Cancer Inst. v.3 Histochemical and morphologic differentiation of induced tumors of the liver in rats Firminger,H.I.;Mulay,A.S.
  10. Arch. Pathol. v.83 Recent observation of the concept of metastasis Fisher,E.R.;Fsher,B.
  11. Cancer Lett. v.41 Glutathione and enzymes related to free radical metabolism in liver of rats fed a choline-devoid low methionine diet Ghoshal,A.;Roomi,M.W.;Ahluwalia,M.;Simmonds,W.;Rushmore,T.H.;Farber,E.;Ghoshal,A.K.
  12. Cancer Res. v.36 Sex hormones and hepatic neoplasia Goldfarb,S.
  13. J.A.M.A. v.178 Role of injury and hyperplasia in the induction of hepatocellular carcinoma Goldfarb,S.;Zak,F.G.
  14. J. Path. Bact. v.LXXII Nodular cirrhosis and metastasising tumours produced in the liver of rats by prolong feeding with thioacetamide Gupta,D.N.
  15. Cancer Lett. v.32 Effect of timing of partial hepatectomy on the inducction of preneoplastic liver foci in rats given hepatocarcinogens Hasegawa,R.;Tsud,H.;Shirai,T.;Kurata,Y.;Masuda,A.;Ito,N.
  16. Arch. Pathol. v.12 Experimental pathology of the liver; I.Restoration of the white rat following partial surgical removal Higgins,G.M.;Anderson,R.M.
  17. Monographs on the evaluation of the carcinogenic risk of chemicals to humans v.1-37 IARC
  18. Toxicol. Forum. v.9 Development of new rapid bioassay for carcinogens to predict the results of long term carcinogenicity test Ito,N.;Inoue,T.;Tagawa,Y.;Aoki,T.;Kahawa,M.
  19. Gann v.71 The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rasts treated with N-nitrosodiethylamine or N-2-acetaminofluorene Ito,M.;Tatematsu,M.;Nakanishi,K.;Hasegawa,R.;Takano,T.;Imaida,K.;Ogiso,T.
  20. J. Korean Cancer Asso. v.20 The promoting effect of capsaicin on the development of diethylnitrosamine initiated enzyme altered hepatic foci in male Sprague-Dawley rats Jang,J.J.;Kim,S.H.
  21. Biochem. Biophys. Acta. v.738 Formation of DNA modifications by chemical carcinogens identification, localization and quantification Kriek,E.;Englelse,L.D.;Scherer,E.;Westra,J.G.
  22. Cancer v.62 The association of hepatocellular carcinoma in childhood with hepatitis B virus infection Leuschner,I.;Harms,D.;Schmidt,D.
  23. J. Natl. Canncer Inst. v.79 Long-term studies on carcinogenicity and promoting effect of phenylbutazone in DONRYU rats Maekawa,A.;Onodera,H.;Tanigawa,H.;Furuta,K.;Kanno,J.;Matsuoka,C.;Ogiu,T.;Hayashi,Y.
  24. Brit. J. Cancer v.10 The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine Magee,P.N.;Barnes,J.M.
  25. Federation Proc. v.35 Carcinogens occuring naturally in foods Miller,J.A.;Miller,E.C.
  26. Response of the liver in Toxicology of the Liver Assessment of the hepatocarcinogenic potential of chemicals Newberne,P.M.;Plaa,G.L.(ed.);Hewitt,W.R.(ed.)
  27. Cancer v.6 Serum glutathione-s-transferase-π as a tumor marker for gastrointestinal malignancies Niitsu,Y.;Takahashi,Y.;Saito,T.;Hirata,Y.;Arisato,N.;Maruyama,H.;Kohgo,Y.;Listowsky,I.
  28. Cancer Res. v.46 Mechanisms of tumor progression Nowell,P.C.
  29. Lab. Invest. v.41 Sequential analysis of hepaticc carcinogenesis Ogawa,K.;Medline,A.;Farber,F.
  30. Cancer Res. v.35 Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydration, and dichlorodiphenyltrichloroethane of 2-acetylaminofluoreneinduced hepatic tumorigenesis in the rat Peraino,C.;Michael Fry,R.J.;Staffeldt,E.;Christopher,J.P.
  31. Genn v.80 Progression: The terminal stage in carcinogenesis Pitot,H.C.
  32. Am. J. Pathol. v.89 The natural history of neoplasia Pitot,H.C.
  33. Cancer Res. v.32 Growth kinetics of diethylnitrosamine-induced, enzyme-deficient "preneoplastic" liver cell population in vivo and in vitro Rabes,H.M.;Scholze,P.;Jantsch,B.
  34. The epidemiology of cancer and biology of tumor metastasis in Cancer Biology (2nd ed.) Rudon,R.W.
  35. Cancer Res. v.47 Effects of rat strain, diet composition, and phenobarbital on hepatic γ-glutamyl transpeptidase histochemistry and on the indduction of altered hepatocyte foci and hepatic tumors by diethylnitrosamine Russell,J.J.;Staffeldt,F.;Wright,B.J.;Prapuolenis,A.;Carnes,B.A.;Peraino,C.
  36. J.Korean Toxicol. v.4 Glutathion s-transferases and chemical carcinogenesis; GST-P as a preneoplastic marker Sato,K.
  37. Tumours of the liver in Pathology of Tumours in Laboratory Animals Schaurer,A.;Kunze,E.;Turusov,V.S.(ed.)
  38. Cancer Res. v.36 Kinetics of inuction and growth of enzyme deficient islands involved in hepatocarcinogenesis Scherer,E.;Emmelot,P.
  39. Cancer Res. v.43 Promotion of liver cancer developement by brief exposure to dietary 2-acetaminofluorene plus partial hepatectomy or carbon tetrachloride Solt,D.B.;Cayama,E.;Tsuda,H.;Enomoto,K.;Lee,G.;Farber,E.
  40. Am. J. Pathol. v.88 Rapid emergence of carcinogeniduced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis Solt,D.B.;Medline,A.;Farber,E.
  41. Nature v.263 New principle for the analysis of chemical carcinogenesis Solt,D.;Farber,E.
  42. Cancer Res. v.47 Progression in hepatocarcinogenesis: Differences in growth and behavior of transplasnts of early and later hepatocyte nodules in the rat spleen Tatematsu,M.;Lee,G.;Hayes,A.;Farber,E.
  43. Gann v.71 A sequential quantitative study of the reversibility or irreversibility of liver hyperplastic nodules in rats exposed to hepatocarcinogens Tatematsu,M.;Takano,T.;Hasegawa,R.;Imaida,K.;Nakanowatari,J.;Ito,N.
  44. Cancer Lett. v.27 Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase Thamavit,W.;Tatematsu,M.;Ogiso,T.;Mera,Y.;Tsuda,H.;Ito,N.
  45. Gann v.75 Modifying potential of thirty-one chemicals on the short-term development of γ-glutamyl transpepeptidase-positive foci in diethylnitrosamin-initiated rat liver Tsuda,H.;Hasegawa,R.;Imaida,K.;Masui,T.;Moore,M.A.;Ito,N.
  46. Chemical carcinogens in Casarett and Doull's Toxicology Chemical carcinogens in Casarett and Doull's Toxicology Williams,G.M.;Weisburger,J.H.;Klassen,C.D.(ed.);Amdur,M.O.(ed.);Doull,J.(ed.)
  47. Biochem. Biophys. Acta v.605 The pathogenesis of rat liver cancer caused by chemical carcinogens Willams,G.M.