Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Optical resolution of Aminoalcohol with Active Cyclic 1,1'-bi-2-naphthol Phosphoric Acid

1, 1'-bi-2-naphthol 환상의 인산에스테르 화합물(化合物)을 이용(利用)한 아미노알코올의 광학분할(光學分割)

  • Park, Heung-Cho (Dept. of Industrial Chemistry, Chung Ju Technical Junior College) ;
  • Lee, Gyung-Won (Dept. of Industrial Chemistry, Chung Ju Technical Junior College)
  • 박흥조 (청주공업전문대학 화공과) ;
  • 이경원 (청주공업전문대학 화공과)
  • Published : 1990.05.31
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Abstract

Optical resolution of aminoalcohols had been achived efficiently by use of (R)-2,2'-dihydroxy-l,1'-binaphtholphosphoric acid as the resolving agent in various organic solvents. Racemic aminoalcohols were resolved very easily and high enantiomer yield (about 70% e,e) in THF. On the other hand, absolute configuration of resolved aminoalcohol was (R)-configuration but one of the Valinnol and Phhenylglycinol was anti-type because of sterichindrance.Optical resolution of aminoalcohols had been achived efficiently by use of (R)-2,2'-dihydroxy-1,1'-binaphtholphosphoric acid as the resolving agent in various organic solvents. Racemic aminoalcohols were resolved very easily and high enantiomer yield (about 70% e,e) in THF. On the other hand, absolute configuration of resolved aminoalcohol was (R)-configuration but one of the Valinnol and Phhenylglycinol was anti-type because of sterichindrance.

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