Archives of Pharmacal Research
- Volume 13 Issue 1
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- Pages.64-68
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- 1990
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
A study of stabilization effect of .alpha.-tocopherol incorporated into liposomal phospholipid membrane
- Bae, Song-Ja (Deparment of Food and Nutrition, Pusan Womens University) ;
- Kim, Nam-Hong (College of Pharmacy, Pusan National University)
- Published : 1990.03.01
Abstract
The stabilization effect of .alpha.-tocopherol incorporated into liposomal phospholipid membrane was investigated by fluorospectrophotometry and UV-visible spectretarded by the presence of .alpha.-tocopherol in the bilayer of liposomal phospholipid membrane relative to cholesterol-containing liposomes and pure phospholipid liposomes. .alpha.-tocopherol-containing liposomes prolonged the oxidation of liposomes-embedded heme as those of cholesterol-containing liposomes and pure phospholipid liposomes. Thus .alpha.-tocopherol-containing liposomes may be useful for the carrier systems of nutrients and drugs to phospholipid bilayer and stabilized liposomes.
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