YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Evaluation of Transdermal Patch for Antiviral Agent

항바이러스제 Transdermal Patch의 제조와 평가

  • Choi, Seung-Ho (Department of Pharmaceutics, College of Pharmacy, University of Utah) ;
  • Kim, Johng-Kap (College of Pharmacy, Chung-Ang University)
  • Published : 1990.12.28
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Abstract

Transdermal patches and polymer membrane were prepared and evaluated for their ability to antiviral agent in vitro. The membrane perpared with styrene and HEMA by 0.5 and 10% of styrene composition. And the transdermal patches were fabricated with this membrane and silastic silicone sheeting. The antiviral agents used were ACV, BVDU and FEAU. The higher HEMA content membranes exhibited relatively high release rate of each drug. Permeation was enhanced by increasing of drug concentration. The parameters of each drug in diffusion experiment with styrene-HEMA membrane were investigated.

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