Journal of Yeungnam Medical Science
- 제6권2호
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- Pages.207-215
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- 1989
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- 2799-8010(eISSN)
Minaprine의 말초 항콜린 효과에 관한 연구
A Study on the Pheripheral Anticholinergic Effect of Minaprine
- Park, Mook-Hee (Department of Neuropsychiatry, Pohang Medical Center) ;
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Lee, Jong-Bum
(Dept. of Psychiatry, College of Medicine, Yeung Nam University) ;
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Cheung, Seung-Douk
(Dept. of Psychiatry, College of Medicine, Yeung Nam University)
- 발행 : 1989.12.30
초록
Minaprine의 말초 항콜린 작용 유무를 판별하기 위하여 백서를 단두 사혈하여 적출된 십이지장, 상행결장, 방광으로부터의 평활근 절편을 사용하여 atropine의 bethanechol 작용 차단 능력을 기준으로 하여 minaprine의 차단 능력을 비교하여 다음과 같은 결과를 얻었다. 십이지장 절편에서 atropine
The authors studied ED50 of bethanechol on the contractilities of the smooth muscles isolated from various organs of rat under the presence of atropine(a classical competitive blocker of cholinergic muscarinic receptor) or minaprine(a newly developed antidepressant drug) to investigate the pheripheral anticholinergic effect of minaprine. The results were as follows ; 1) There was no significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine
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