Studies on the Efficacy of Combined Preparations of Crude Drug(XL) -Effect of Sagan-Tang on the Central Nervous, Cardiovascular System and the Liver Damage-

생약복합제제(生藥複合製劑)의 약효(藥效) 연구(硏究) 제40보(第40報) -사간탕(瀉肝湯)이 중추신경계(中樞神經系), 순환기계(循環器系) 및 간독성(肝毒性에 미치는 작용(作用)-

Experimental studies were conducted to investigate the effect of Sagan-Tang on analgesic, sedative, antipyretic, isolated ileum and blood vessel and so on. The results of this investigation were summarized as follows; Analgesic action by the acetic acid stimulating method in mice were recognized. Prolonging action against the hypnotic duration induced by thiopental-Na was noted in mice. Antipyretic effect in typhoid vaccine febrile rats was recognized. Spontaneous motility of the isolated ileum of mice was suppressed and contractions of the isolated ileum of mice and guinea-pig induced by accetylcholine chloride, barium chloride and histamine were remarkably inhibited. Vaso-diating and hypotensive actions were recognized in rabbits. GOT and GPT activities in the serum of rats damaged by $CCl_4$ and galactosamine were decreased remarkably.