Journal of Pharmaceutical Investigation

  • 제17권4호
  • /
  • Pages.213-216
  • /
  • 1987
  • /
  • 2093-5552(pISSN)
  • /
  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
권호 표지

유전자 조작 알파 인터페론의 조직분포에 관한 연구

Study on Tissue Distribution of Recombinant Human Alpha-Interferon

  • 김제학 (제일제당(주) 종합연구소) ;
  • 이혜선 (제일제당(주) 종합연구소) ;
  • 김달현 (제일제당(주) 종합연구소) ;
  • 조남진 (제일제당(주) 종합연구소) ;
  • 곽규범 (제일제당(주) 종합연구소)
  • 발행 : 1987.12.20
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초록

The distribution features of recombinant human $alpha-interferon(rHuIFN-{\alpha}A)$ and $^{14}C-radiolabeled\;rHuIFN-{\alpha}A\;(^{14}C-rHuIFN-{\alpha}A)$ were investigated in ICR mice after i.v. injection. The level of $rHuIFN-{\alpha}A$ in the kidney was significantly higher than those in lung and liver at 10min after the injection. But the level was reduced significantly at 60min. The level of radioactivity in the kidney was also significantly higher than those in other organs after i.v. injection of $^{14}C-rHuIFN-{\alpha}A$, but it was reduced at much slower speed than was $rHuIFN-{\alpha}A$. These results show that interferon is distributed repidly and the kidney is the main site of distribution and metabolism of $rHuIFN-{\alpha}A$.

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