Journal of Pharmaceutical Investigation
- 제17권4호
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- Pages.205-211
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- 1987
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
실험적 신장해 모델의 특성 비교
Characteristics of Some Animal Models of Experimental Renal Failure
초록
Renal dysfunction can have pronounced effects on the pharmacokinetic and pharmacodynamic characteristics of drugs. Because the exploration of these effects in patients may be limited by ethical and practical considerations, it often become necessary to perform studies on animals with experimental renal failure(ERF). ERF was produced in rats by the administration of uranyl nitrate, glycerol, salicylate, gentamicin and folate in this study. Changes in glomerular filtration rate(GFR) and renal secretion clearance of tetraethylammonium bromide
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