Bulletin of the Korean Chemical Society

  • 제7권3호
  • /
  • Pages.213-217
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  • 1986
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  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Preparation of Glutamic Acid-Leucine Copolymer Containing Indomethacin for Controlled Delivery

  • Yeom, Young-Il (Department of Biological Science & Engineering, The Korea Advanced Institute of Science & Technology) ;
  • Kim, Hyun-Pyo (Department of Biological Science & Engineering, The Korea Advanced Institute of Science & Technology) ;
  • Kim, Hack-Joo (Department of Biological Science & Engineering, The Korea Advanced Institute of Science & Technology) ;
  • Byun, Si-Myung (Department of Biological Science & Engineering, The Korea Advanced Institute of Science & Technology) ;
  • Kim, Nam-Deuk (College of Pharmacy, Pusan National University)
  • 발행 : 1986.06.20
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초록

A series of copolypeptides of glutamic acid and leucine have been synthesized by N-carboxy-${\alpha}$-amino acid anhydride procedure and cast to form injectable microparticulate monolithic devices in which indomethacin was physically dispersed. With these devices, various release properties and possible clinical application were studied. The release rate of the drug had a close relationship with the monomer composition of the copolymer matrix as well as the environmental pH condition. The monolithic device of glutamic acid/leucine = 50/50 was found to be the most promising one as a ploymeric delivery system of indomethacin. The intrinsic viscosity of this copolymer was 4.35 dl/g and the release rate was 18.5${\mu}g/g/day$.

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참고문헌

  1. Controlled Release of Biologically Active Agents A.C. Tanguary;R.E. Lacey
  2. J. Pharm. Sci. v.61 T.J. Roseman
  3. Acta Endocrinol. v.63 G. Genagiano;M. Ermini;C.C. Chang;K. Sundaram;F.A. Kind
  4. Controlled Release of Bioactive Materials R.V. Petersen;C.G. Anderson;S.M. Fang;D.E. Gregonis;S.W. Kim;J. Feijen;J.M. Anderson;S. Mitra;R. Baker(ed.)
  5. Polymeric Delivery Systems J.C. Venter;M.S. Verlander;N.O. Kaplan;M. Goodman;J. Ross Jr.;S. Sesayama;R.J. Kostelnik(ed.)
  6. J. Am. Chem. Soc. v.74 R.R. Becker;M.A. Stahmann
  7. J. Am. Chem. Soc. v.78 E.R. Blout;R.H. Karlson
  8. Remington's Pharmaceutical Sciences
  9. J. Chromatogr. v.172 L.J. Dusci;L.P. Hackette
  10. J. Am. Chem. Soc. v.76 P. Doty;A.M. Holtzer;J.H. Bradbury;E.R. Blout
  11. J. Chem. Soc. W.E. Hanby;S.G. Waley;J. Watson
  12. Polymer v.16 W.L. Sederel;A. Bantjes;J. Feijen
  13. Biochem. v.3 G. Fasman;C. Lindblow;E. Bodenheimer
  14. J. Biol. Chem. v.115 M. Bergmann;L. Zervas;J.S. Fruton
  15. J. Biol. Chem. v.204 R.R. Becker;M.M. Stahmann
  16. Anal. Chem. v.25 A. Berger;M. Sela;E. Katchalski
  17. J. Biomed. Mater. Res. v.4 C.A. Homsy
  18. Rec. Trav. Chim. v.69 S.G. Waley;J. Watson
  19. Polymeric Delivery System D.L. Wise;A.D. Schwope;S.E. Harrigan;D.A. McCarthy;J.F. Howes;R.J. Kostelnik(ed.)
  20. Controlled Release of Bioactive Materials J. Heller;R.W. Baker;R. Baker(ed.)
  21. Controlled Release of Bioactive Materials C.G. Pitt;T.A. Marks;A. Schindler;R. Baker(ed.)
  22. Biophysical Science P. Doty;J.L. Oncley(ed.)
  23. J. Pharm. Sci. v.70 K.G. Mooney;M.A. Mintun;K.J. Himmelstein;V.J. Stella
  24. Yakhak Hoe Chi v.20 I.K. Jeon;M.W. Lee;C.H. Woo
  25. J. Pharm. Sci. v.66 B.R. Hajratwala;J.E. Dawson