Journal of Pharmaceutical Investigation
- Volume 16 Issue 4
- /
- Pages.135-138
- /
- 1986
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
Antagonism of Analgesic Effect of Morphine in Mice by Ginseng Saponins
인삼 사포닌의 몰핀 길항작용
- Kim, Hack-Seang (College of Pharmacy, Chungbuk National University) ;
- Oh, Ki-Wan (College of Pharmacy, Chungbuk National University) ;
- Oh, Se-Kwan (College of Pharmacy, Chungbuk National University)
- Published : 1986.12.20
Abstract
Ginseng total saponins(GS), protopanaxadiol saponins(PD) and protopanaxadiol saponins(PT) antagonized the analgesia in mice induced by morphine. The administrations of 2,4-dihydroxyphenylalanine, and 5-hydroxytryptophan reduced the GS, PD and PT antagonisms of morphine analgesia. Possible mechanisms involved in the antagonistic actions of GS, PD and PT on morphine analgesia were described.
Keywords