대한화학회지 (Journal of the Korean Chemical Society)

  • 제29권5호
  • /
  • Pages.539-542
  • /
  • 1985
  • /
  • 1017-2548(pISSN)
  • /
  • 2234-8530(eISSN)
대한화학회 (Korean Chemical Society)
권호 표지

Trimethoprim 중간체인 Diethyl 3,4,5-Trimethoxybenzylmalonate의 새로운 합성

A New Route to Diethyl 3,4,5-Trimethoxybenzylmalonate, a Trimethoprim Intermediate

  • 정봉영 (고려대학교 이과대학 화학과) ;
  • 이채호 (고려대학교 이과대학 화학과)
  • 발행 : 1985.10.20
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초록

3,4,5-trimethoxybenzoyl chloride와 diethyl malonate를 축합시킨 후, 염소화반응 및 가수소화 분해 반응을 거쳐 diethyl 3,4,5-trimethoxybenzylmalonate를 70%의 수득율로 합성하였다.

Direct condensation of 3,4,5-trimethoxybenzoyl chloride with diethyl malonate followed by chlorination and hydrogenolysis afforded diethyl 3,4,5-trimethoxybenzylmalonate in 70% overall yield.

키워드

참고문헌

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