Archives of Pharmacal Research
- Volume 7 Issue 2
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- Pages.141-143
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- 1984
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Biotransformation of benzyle trans-2-phenylcyclopropanecarbamate to tranylcypromine in rats
- Il, Kang-Gun (College of Pharmacy, Sookmyung Womens University) ;
- Chung, Soon-Young (College of Pharmacy, Sookmyung Womens University)
- Published : 1984.12.01
Abstract
A metabolic study was performed in order to characterize the in vivo MAO-inhibitory activity of benzyl trans-2-phenylcylopropanecarbamate which was reported to be twice as potent as the tranylcypromine. In the rat urine which was obtained after the administration of the benzyl trans-2-pheny-lcyclopropanecarbamate (40mg/kg) through oral route, a metabolic product, tranylcypromine as well as the intact drug was detected by GC/MS.
Keywords
- Monoamine osidase inhibition;
- Trnayl-cypromine;
- Benzyl trans-2-phenylcyclopropanecarbamate;
- Metabolic study