Archives of Pharmacal Research
- Volume 7 Issue 2
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- Pages.101-107
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- 1984
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Manifestation of metabolic Aberration in Rat urine Following Hypothalamic Lesions
- Anbar, Michel (Department of Biophysical Sciences, School of Medicine, State University of New York at Buffalo) ;
- Kim, Kyoung-Rae (College of Pharmacy, Sung Kyun Kwan University)
- Published : 1984.12.01
Abstract
The concentrations of metabolites of low molecular weights (90 to 310 amu) present in rat urine were determined by field ionization mass spectrometry. Three groups of rats were examined; intact controls, sham-operated rats and rats with selective lesions in their hypothalamus. The latter lesions are shown to induce characteristic aberrations in the metabolic profile, demonstrable five weeks after treatment, which are distinct from those induced by a sham operation.
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