Journal of Pharmaceutical Investigation
- Volume 11 Issue 2
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- Pages.16-19
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- 1981
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Some Factors Influencing the Dissolution Rate of Lorazepam Formulations
Lorazepam제제(製劑)의 용출속도(溶出速度)에 미치는 인자(因子)
- Lee, Chang-Ki (Department of Pharmacy. The National Medical Center) ;
- Song, In-Jung (Department of Pharmacy. The National Medical Center) ;
- Choi, Jung-Young (Department of Pharmacy. The National Medical Center) ;
- Suh, Sung-Won (Department of Pharmacy. The National Medical Center)
- Published : 1981.06.20
Abstract
The effect of diluents and lubricants on the dissolution rate of lorazepam was studied. The results were as following. 1. An average order of dissolution rate can be stated as; lactose> avicel> starch> kaolin. 2. The effects of lubicants is not significant generally but in the case of starch the dissolution rate is greatly effected by magnesium stearate.
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