Studies on the Variation of Nonprotein Nitrogen Compounds in the Blood of Rabbits Administered with Panax ginseng -Mainly on the Variation of Ammonia Value in the Blood of Portal Vein-

인삼투여가토(人蔘投與家兎)의 혈액내(血液內) 비단백성질소함량(非蛋白性窒素含量)의 변화(變化)에 관한 연구(硏究) -문맥(門脈) 혈액(血液) 암모니아치(値)의 변화(變化)를 중심(中心)으로-

The present study was carried out to evaluate the effect of Panax ginseng on the metabolism of nonprotein nitrogen compounds in rabbit blood. After rabbits were administered with ginseng powder orally for 30 days or with ginseng extract intraperitoneally for 10 days, the blood was collected from portal and ear vein to measure ammonia, urea, creatinine and nonprotein nitrogen. The blood ammonia level in ear vein of control rabbits was $87.0{\pm}5.1{\mu}g/100ml$ and was not significantly different from that of rabbits which were administered with ginseng powder orally or with ginseng extract intraperitoneally. But oral administration of ginseng powder produced a great decrease in ammonia level of portal vein from 1,392 to $704{\mu}g$ per 100ml, suggesting that intestinal ammonia production is suppressed by ginseng powder due to its antimicrobial activity. While there was no significant difference between the control and the rabbits which were administered with ginseng extract intraperitoneally. Ginseng administration had no effect on the creatinine level in blood from ear and portal vein, except the intraperitoneal injection of ginseng extract. It slightly lowered the creatinine level only in ear vein blood. The values of urea and nonprotein nitrogen were net affected by the administration of ginseng.