The Korean Journal of Pharmacology (대한약리학회지)

The Korean Society of Pharmacology (대한약리학회)
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Clinical Evaluation of Efficacy of Moltase by Double-blind Test

Double-blind test에 의한 Moltase 의 효력평가(?力評價)

  • Lee, Tong-Ho (Depts. of Pharmacology & Internal Medicine, Chonnam Univ. Medical School) ;
  • Lee, Tae-Hee (Depts. of Pharmacology & Internal Medicine, Chonnam Univ. Medical School)
  • 이동호 (전남대학교 의과대학 약리학교실.내과학교실) ;
  • 이태희 (전남대학교 의과대학 약리학교실.내과학교실)
  • Published : 1970.06.30
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Abstract

1) Efficacy of Moltase, a digestive enzyme preparation, was evaluated by double-blind test. 2) The clinical symptoms assessed in this study were anorexia, vomiting, nausea, eructation, hunger pain, epigastralgia, fullness in epjgastrium, abdominal fullness, constipation, and diarrhea. Effect of Moltase on gastric acidity was also examined by double-blind test. 3) People subjected to this study were 42 students and 22 patients who had signs of chronic dyspepsia. 4) In general, the clinical symptoms were more effectively improved by Moltase than placebos. The marked differences in efficacy between both medication were observed in epigastralgia, fullness in epigastrium, abdominal fullness, and anorexia. 5) Six out of 9 patients with no free gastric acid became to have free gastric acid after Moltase medication.

소화불량(消化不良)을 호소(呼訴)하는 학생(學生) 및 환자(患者)에게 placebos 투여(投與) 및 double-blind test에 의하여 식욕부진(食慾不振), 구역, 구토, 트림, 공복통(空腹痛), 상복부통(上腹部痛), 상복부포만감(上腹部飽滿感), 복부팽만(腹部膨滿), 변비(便秘), 설사(泄瀉) 등의 증상(症狀) 및 위산도(胃酸度)에 대한 Moltase의 효력(?力)을 평가(評價)할 것을 시도(試圖)하여 1) 전반적(全般的)으로 Moltase투여(投與)가 placebos 투여(投與)보다 소화불량증상(消化不良症狀)을 소실(消失) 또는 경감(輕減)시키는 효력(?力)이 켰으며 특히 상복부통(上腹部痛), 상복부포만감(上腹部飽滿感), 복부팽만(腹部膨滿) 및 식욕부진(食慾不進)에 대하여 현저(顯著)한 치료효과(治療?果)가 있으며, 2) 유리위산(遊離胃酸)을 증명(證明)치 못하였던 9명(名)의 환자중(患者中) 6명(名)에서 Moltase 복용후(服用後) 유리위산(遊離胃酸)을 증명(證明)케 되었다.

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