Acknowledgement
본 연구는 2022년도 교육부의 재원으로 한국연구재단의 지자체-대학 협력기반 지역혁신 사업(사업번호: 2021RIS-001)의 지원에 의해 이루어진 결과로 이에 감사드립니다.
Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2022.09a
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- Pages.110-110
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- 2022
Inhibitory Effects on Melanogensis of Scrophularia koraiensis Nakai in Melanocytes
- So-Yeon Han (Medicinal Plant Science, Jungwon University) ;
- Hye-Jeong Park (Medicinal Plant Science, Jungwon University) ;
- Da-Yoon Lee (Medicinal Plant Science, Jungwon University) ;
- Seo-Yoon Park (Department of Pharmaceutical Science, Jungwon University) ;
- Jun-Hwan Jeong (Department of Pharmaceutical Science, Jungwon University) ;
- Yoon-Jae Kwon (Department of Pharmaceutical Science, Jungwon University) ;
- Tae-Won Jang (Pharmaceutical Science, Jungwon University) ;
- Jae-Ho Park (Pharmaceutical Science, Jungwon University)
- Published : 2022.09.27
Abstract
Scrophularia koraiensis Nakai (S. koraiensis) has used its roots as traditional herbal medicine. Some research is reported to be effective in allergic inflammation and osteoporosis. In a present study, we conducted to investigate the bioactivity of the ethanol extract of S. koraiensis (ESK) on the inhibition of melanogenesis and the apoptosis of melanocytes. We analyzed Harpagoside of ESK by using LCMS and HPLC-PDA and investigated the regulation of ESK on reactive oxygen species. Also, the expressions of melanin synthesis-related factors and apoptosis-related factors were confirmed. As a result, the quantification results of quercetin and rutin in ESK were 77.2 and 7.4 mg/g. IC50 on DPPH and ABTS radical scavenging activity is 33.1 and 9.5 ug/mL. ESK attenuated not only the expression of tyrosinase, TYRP-1, TYRP-2, and MITF in melanogenesis. It is thought that ESK may be effective in the inhibition of melanogenesis through MAPK cell signaling pathway in melanocytes. These study results suggest that ESK has the ability to inhibit melanin production and induce apoptosis.
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