Acknowledgement
본 연구는 2022년도 교육부의 재원으로 한국연구재단의 지자체-대학 협력기반 지역혁신 사업(사업번호: 2021RIS-001)의 지원에 의해 이루어진 결과로 이에 감사드립니다.
Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2022.09a
- /
- Pages.109-109
- /
- 2022
Astilboides tabularis (Hemsl.) Engl. Exerts Anti-inflammatory Effects through NF-κB Signaling Pathway in Lipopolysaccharide (LPS)-induced RAW 264.7 Cells
- Hye-Jeong Park (Medicinal Plant Science, Jungwon University) ;
- So-Yeon Han (Medicinal Plant Science, Jungwon University) ;
- Da-Yoon Lee (Medicinal Plant Science, Jungwon University) ;
- Seo-Yoon Park (Department of Pharmaceutical Science, Jungwon University) ;
- Jun-Hwan Jeong (Department of Pharmaceutical Science, Jungwon University) ;
- Yoon-Jae Kwon (Department of Pharmaceutical Science, Jungwon University) ;
- Tae-Won Jang (Pharmaceutical Science, Jungwon University) ;
- Jae-Ho Park (Pharmaceutical Science, Jungwon University)
- Published : 2022.09.27
Abstract
Astilboides tabularis (A. tabularis) has been thought to be material for functional food and could help to prevent diabetes for centuries. A. tabularis has been reported to contain phytochemicals (catechin, chlorogenic acid, and rutin), which have antioxidant and anti-inflammatory effects. We focused on anti-inflammatory effects of ethyl acetate fraction of A. tabularis (EAT) through NF-κB signaling pathway. Phytochemicals of EAT were analyzed by total flavonoid and phenolics assay, its content was 219.2 ± 2.01 and 524.7 ± 0.80 mg/g respectively. EAT significantly reduced the expression of iNOS and COX-2, which caused the production of nitric oxide (NO). EAT suppressed mRNA levels of iNOS, COX-2, and cytokines (IL-6, IL-1β, and TNF-α). EAT suppressed the expression of p-p65 through the inhibition of phosphorylation of IkB-a, and the result of immunofluorescence showed that inhibited the translocation of p65 from the cytoplasm to the nucleus.
Keywords