Acknowledgement
본 연구는 수원대학교 교내연구진흥기금의 지원에 의해 이루어진 결과로 이에 감사드립니다.
Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2022.09a
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- Pages.96-96
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- 2022
Anti-Inflammatory and Cytotoxic Effects of Dillenia Extracts
딜레니아 추출물의 항염증 효능과 세포독성안전성
- Jiyoon Jung (Department of Biotechnology, The University of Suwon) ;
- Eunji Lee (Department of Biotechnology, The University of Suwon) ;
- Dasol Kang (Department of Biotechnology, The University of Suwon) ;
- Soohyang Lim (Department of Biotechnology, The University of Suwon) ;
- Hyunji Oh (Department of Biotechnology, The University of Suwon) ;
- Sooyoung Jun (Department of Biotechnology, The University of Suwon) ;
- Haeri Shin (Department of Biotechnology, The University of Suwon) ;
- June Hyun Kim (Department of Biotechnology, The University of Suwon)
- 정지윤 (수원대학교 바이오공학과) ;
- 이은지 (수원대학교 바이오공학과) ;
- 강다솔 (수원대학교 바이오공학과) ;
- 임수향 (수원대학교 바이오공학과) ;
- 오현지 (수원대학교 바이오공학과) ;
- 전수영 (수원대학교 바이오공학과) ;
- 신혜리 (수원대학교 바이오공학과) ;
- 김준현 (수원대학교 바이오공학과)
- Published : 2022.09.27
Abstract
Dillenia turbinata Finet & Gagnep. has been known to be used for couch cold, Clerodendrum japonicum (Thunb.) Sweet for pimple, Garcinia tinctoria (DC.) Dunn for oedema. and Garcinia cowa Roxb. for detoxification for a long time. To determine whether these plants have anti-inflammatory effects, we performed nitric oxide (NO) assay. Raw264.7 cells were stimulated with LPS and treated with methanol extracts of these plants. Garcinia cowa Roxb. did not relatively show anti-inflammatory effect, compared to Redcharm extract control as previously used. However, Dillenia, Clerodendrum and Garcinia tinctoria demonstrated significantly higher anti-inflammatory effects in NO assay. We then tested whether these extracts have cytotoxic effect with MTT assay in Raw264.7 cells. Dillenia, Clerodendrum, Garcinia tinctoria and Garcinia cowa Roxb. showed almost similar cell survival rate. This implies that all these plants have almost no significant cytotoxic effects. Taken together, these results suggest that Dillenia, Clerodendrum, and Garcinia tinctoria, but not Garcinia cowa Roxb. are a good anti-inflammatory agent to be developed for medical applications.
Keywords