Proceedings of the Korean Society for Emotion and Sensibility Conference (한국감성과학회:학술대회논문집)

Korean Society for Emotion and Sensibility (한국감성과학회)
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Vitamin E protects neurons against kainic acid-induced neurotoxicity in organotypic hippocampal slice culture

뇌 해마 절편 배양 모델에서 흥분 독성에 대한 비타민 E의 신경 보호 효과

  • Kim, Ga-Min (Department of Physiology, Yonsei University College of Medicine) ;
  • Jung, Na-Young (Department of Physiology, Yonsei University College of Medicine) ;
  • Lee, Kyung-Hee (Department of Physiology, Yonsei University College of Medicine) ;
  • Kim, Hyung-A (Department of Physiology, Yonsei University College of Medicine) ;
  • Kim, Un-Jeng (Department of Physiology, Yonsei University College of Medicine) ;
  • Lee, Bae-Hwan (Department of Physiology, Yonsei University College of Medicine)
  • Published : 2009.11.20
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Abstract

Kainic acid (KA), an agonist for kainate and AMPA receptors, is an excitatory neurotoxic substance. Vitamin E such as alpha-tocopherol and alpha-tocotrienol is a chain-breaking antioxidant, preventing the chain propagation step during lipid peroxidation. In the present study, we have investigated the neuroprotective effects of alphatocopherol and alpha-tocotrienol on KA-induced neuronal death using organotypic hippocampal slice culture (OHSC). After 15h KA treatment, delayed neuronal death was detected in CA3 region. Alpha-tocopherol and alpha-tocotrienol increased cell survival and reduced the number of TUNEL-positive cells in CA3 region. These data suggest that alpha-tocopherol and alpha-tocotrienol treatment have protective effects on KA-induced cell death

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