한국생물정보학회:학술대회논문집 (Proceedings of the Korean Society for Bioinformatics Conference)
- 한국생물정보시스템생물학회 2004년도 The 3rd Annual Conference for The Korean Society for Bioinformatics Association of Asian Societies for Bioinformatics 2004 Symposium
- /
- Pages.77-85
- /
- 2004
AU-rich elements (ARE) found in the U-rich region of Alu repeats at 3' untranslated regions
- An, Hyeong-Jun (Department of BioSystems, KAIST) ;
- Lee, Kwang-Hyung (Department of BioSystems, KAIST) ;
- Bhak, Jong-Hwa (Department of BioSystems, KAIST, NGIC, KRIBB, Object Interaction Technologies (OITEK), Inc., BiO Centre) ;
- Lee, Do-Heon (Department of BioSystems, KAIST)
- 발행 : 2004.11.04
초록
A significant portion (about 8% in human genome) of mammalian mRNA sequences contains AU(Adenine and Uracil) rich elements or AREs at their 3' untranslated regions (UTR). These mRNA sequences are usually stable. ARE motifs are assorted into three classes. The importance of AREs in biology is that they make certain mRNA unstable. We analyzed the occurrences of AREs and Alu, and propose a possible mechanism on how human mRNA could acquire and keep A REs at its 3' UTR originated from Alu repeats. Interspersed in the human genome, Alu repeats occupy 5% of the 3' UTR of mRNA sequences. Alu has poly-adenine (poly-A) regions at the end that lead to poly -thymine (poly-T) regions at the end of its complementary Alu. It has been discovered that AREs are present at the poly -T regions. In the all ARE's classes, 27-40% of ARE repeats were found in the poly -T region of Alu with mismatch allowed within 10% of ARE's length from the 3' UTRs of the NCBI's reference m RNA sequence database. We report that Alu, which has been reported as a junk DNA element, is a source of AREs. We found that one third of AREs were derived from the poly -T regions of the complementary Alu.
키워드