대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.188.1-188.1
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- 2003
Total Synthesis of New Apicidin Derivatives as Potent Antitumor Agents
- kim, hyung-Kyo ;
- Jin, Cheng-Hua ;
- Han, Jeong-Whan ;
- Lee, Hyang-Woo ;
- Lee, Yin-Won ;
- Zee, Ok-Pyo ;
- Jung, Young-Hoon
- 발행 : 2003.10.01
초록
The antiparasitic agent apicidin, which was recently isolated from cultures of Fusarium Pallidoroseum, belongs to a rare group of cyclictetrapeptide fungal metabolites. Apicidin inhibits protozoal HDAC and is orally active against Plasmodium berghei malaria in mice. The biological activity of apicidin appears to be attributable to inhibition of apicomplexan HDAC at low nanomolar concentrations. In the present, we have worked about the synthesis of new apicidin derivatives and discovered that apicidin and some derivatives have mild antitumor activity. (omiited)
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