대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
- /
- Pages.187.3-188
- /
- 2003
Synthesis and Biological Evaluation of Allylamine Type Antimycotics
- Chung, Soon-Young (College of Pharmacy, Chonnam National University, Gwang Ju 500-757) ;
- Chung, Byung-Ho (College of Pharmacy, Chonnam National University, Gwang Ju 500-757)
- 발행 : 2003.10.01
초록
Structure-activity relationship studies of allylamine type of antimycotics were carried out to evaluate the effect of naphthyl and methyl portion of naftifine. Compounds with 4-fluorphenyl, 2-fluorophenyl, 2,4-dichlorophenyl, 2,6-dichlorophenyl, 4-nitrophenyl, and 2,3-dihydro-benzo[l,4]dioxin-6-yl instead of naphthyl group with hydrogen, methyl, and ethyl in the place of methyl in naftifine were synthesized and tested their in vitro anti-fungal activity against five different fungi. Eight compounds showed significant antifungal activity against T. mentagrophytes. (omitted)
키워드