대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.156.2-157
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- 2003
Inhibition of nitric oxide and TNF-$\alpha$ production by propenone compound through blockaded of NF-$\kappa$ B activation in cultured murine macrophages
- Ju, Hye-Kyung (College of Pharmacy, Yeungnam University) ;
- Lee, Eun-Kyung (College of Pharmacy, Yeungnam University) ;
- Jahng, Yurng-Dong (College of Pharmacy, Yeungnam University) ;
- Lee, Eung-Seok (College of Pharmacy, Yeungnam University) ;
- Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University)
- 발행 : 2003.10.01
초록
Lipopolysaccharide (LPS)-stimulated macrophages produced a large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS). This is an important mechanism in macrophages-induced septic shock and inflammation. In the present study, we tested a synthetic propenone compound, l-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) for its ability to inhibit the production of tumor necrosis factor-a (TNF-
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