대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.156.1-156.1
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- 2003
The roles of ceramide on the cellular signal transduction in RAW 264.7 murine macrophages activated with lipopolysaccharide and interferon-gamma.
- Park, Sung-Sik (Department of Immunology, College of Pharmacy, Chung-Ang University) ;
- Chun, Young-Jin (Department of Immunology, College of Pharmacy, Chung-Ang University)
- 발행 : 2003.10.01
초록
Cerarmide acts as a lipid second messenger in the cellular signal transduction and is involved in mediating a variety of cell functions such as proliferation, differentiation, growth arrest, and apoptosis. In the present study, we have investigated the effect of ceramide on cellular cytotoxity and reactive oxygen species (ROS) to understand the relationship between them. Ceramide treatment significantly increased cell death in RAW 264.7 murine macrophages activated with lipopolysaccharide (LPS) and interferon-g (IFN-g). (omitted)
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